Cytotoxicity and Antioxidant Activity of a Streptomyces Sp. from Mangrove Sediments of Dar Es Salaam, Tanzania

Objective: The present study aimed at screening for cytotoxicity and antioxidant properties of extract from Streptomyces sp. isolated from Dar es Salaam mangrove sediments. Methods: The Streptomyces sp. (isolated in a previous study), was cultivated in broth and the non polar fractions of its extracellular metabolites were harvested via ethyl acetate (liquid-liquid) extraction. The obtained extract was first screened for cytotoxicity activity using brine shrimp lethality bioassay. Antioxidancy was assessed on the basis of scavenging ability of the stable 1, 1 Diphenyl-2-picry Hydrazyl (DPPH). Results: The extract was found to possess cytotoxicity activity with the LC50 Conclusion: The findings indicate that, the marine Streptomyces sp. could be a promising source for novel drug discovery in the pharmaceutical industry. value of 236.86μg/ml. On screening for antioxidant activity this study found that, the Streptomyces sp. crude extract had Antioxidancy scavenging ability which ranged between 94.31% 95.69% at the concentration from 4200 μg/ml to 14000μg/ml. These findings proved that the strain had potent antioxidant activity as the Ascorbic Acid which is the known antioxidant.